منابع مشابه
Chemokines, lymphocytes, and HIV.
Chemokines are members of a family of more than 30 human cytokines whose best-described activities are as chemotactic factors for leukocytes and that are presumed to be important in leukocyte recruitment and trafficking. While many chemokines can act on lymphocytes, the roles of chemokines and their receptors in lymphocyte biology are poorly understood. The recent discoveries that chemokines ca...
متن کاملNatural killer cells from HIV-1+ patients produce C-C chemokines and inhibit HIV-1 infection.
Human NK cells have been shown to produce cytokines (e.g., IFN-gamma and TNF-alpha) and the chemokine macrophage inflammatory protein (MIP)-1alpha following stimulation with the combination of two monokines, IL-15 plus IL-12. The C-C chemokines MIP-1alpha, MIP-1beta, and RANTES have been identified as the major soluble macrophage-tropic HIV-1-suppressive factors produced by CD8+ T cells, which ...
متن کاملEngineering chemokines to develop putative anti HIV-1 agents
Background Even though, Highly Active Antiretroviral Therapy (HAART) has resulted in significant reduction in mortality associated with Acquired Immune Deficiency Syndrome (AIDS), the side-effects and difficulties in patient compliance warrants the search for new therapeutic options. One potential strategy is to design chemokine analogues that will prevent the entry of human immunodeficiency vi...
متن کاملChemokines and other cytokines in human immunodeficiency virus type 1 (HIV-1) infection
RESUMEN Las citocinas, las quimiocinas y sus receptors son probablemente los principales factores del huésped que influyen en la patogénesis del VIH-1 in vivo. La infección por el VIH-1 estimula la producción de citocinas y quimiocinas en una gran variedad de tipos celulares. Estos factores pueden inducir o inhibir la replicación viral. Además, algunos receptores de quimiocinas actúan como co-r...
متن کاملChemokines and HIV: The First Close Encounter
The first “close encounter” between the fields of chemokines and HIV occurred in the late spring of 1995, when my group at NCI’s Laboratory of Tumor Cell Biology (LTCB) received from Harvard Microchemistry and Proteomics the amino acid sequences of three peptide fragments from an HPLC-purified fraction that we had submitted a few weeks earlier. The sequences showed a perfect match with the huma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurotoxicity Research
سال: 2005
ISSN: 1029-8428,1476-3524
DOI: 10.1007/bf03033826